Active forms of vitamin D and health

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Anna Małgorzata Piotrowska, Olga Czerwińska-Ledwig, Adam Podhorecki, Wanda Pilch

4 (61) 2019 s. 343–351
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Fraza do cytowania: Piotrowska A.M., Czerwińska-Ledwig O., Podhorecki A., Pilch W. Active forms of vitamin D and health. Polski Przegląd Nauk o Zdrowiu. 2019;4(61):343–351. DOI:

Vitamin D was discovered in 1922. It is a substance which has multi-directional effects on human body and has many properties of a hormone. Intracellular receptor of this vitamin is found in the cells in majority of tissues in human body, and is responsible for the effects of its action based on the regulation of gene expression. The supply of this vitamin is associated with dietary intake, as well as the exposure to UV radiation, which leads to its synthesis in the skin. Vitamin D deficiency is very common in the European population. This paper presents a cross-sectional analysis of the effects of vitamin D on human body systems. Physiological processes related to its production, metabolism, the effects of deficiency and excess, analytical methods used to measure the concentration of metabolites of this vitamin in blood serum were discussed. The role of vitamin D in the pathogenesis of various diseases and during pregnancy has also been described.

Key words: vitamin D, pleiotropic action, calcitriol, hipovitaminosis.

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